As de facto prime minister under the regime of Muammar Gaddafi, Saif Gaddafi is wanted by the ICC for crimes against humanity following the outbreak of popular demonstrations in Libya in February 2011. He remains in detention in Libya.

Abdullah al-Senussi, director of military intelligence in the Gaddafi regime, was charged by the ICC with crimes against humanity in 2011. ICC extradition halted after Libya challenged admissibility of the case. Sentenced to death by a Libyan court 2015.

On 2019, former Côte d’Ivoire president Laurent Gbagbo and youth leader Charles Blé Goudé were acquitted of crimes against humanity in the wake of 2010 presidential election after their joint ICC trial opened in January 2016.

The alleged former Lord's Resistance Army commander Dominic Ongwen is charged with 70 counts of war crimes and crimes against humanity in the IDP camps in Northern Uganda. His trial opened on 6 December 2016.

ICC arrest warrants were issued for Joseph Kony and four other senior Lord’s Resistance Army commanders in July 2005 for war crimes and crimes against humanity in northern Uganda. Kony remains wanted.

Former First Lady of Côte d’Ivoire, serving a 20 year prison sentence for undermining state security. Côte d’Ivoire remains obliged to surrender her to The Hague to face charges of crimes against humanity between 2010 and 2011.

Suspected of crimes against humanity and war crimes, alleged executive secretary of the FLDR rebel group Callixte Mbarushimana was released from ICC custody in December 2011 after Pre-Trial Chamber I declined to confirm charges